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dc.creatorFerreira , Márcia Danielle da Silva-
dc.creator.Latteshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4670776A5por
dc.contributor.advisor1Santos, Marcelo Cordeiro dos-
dc.contributor.referee1Lacerda, Marcus vinícius de Guimarães-
dc.contributor.referee2Ruffino Neto, Antônio-
dc.contributor.referee3Santos, Marcelo Cordeiro dos-
dc.date.accessioned2017-03-20T14:22:48Z-
dc.date.issued2015-06-12-
dc.identifier.citationFerreira , Márcia Danielle da Silva. Tuberculose em unidade de terapia intensiva: análise descritiva em um hospital de referência HIV / AIDS na amazônia brasileira. 2015. 79 f. Dissertação (Hematologia) - Universidade do Estado do Amazonas, Manaus.por
dc.identifier.urihttp://tede.uea.edu.br/jspui/handle/tede/231-
dc.description.resumoTuberculose (TB) é reconhecida como grave problema de saúde pública. No Amazonas, em 2014, a letalidade por TB foi de 3,5/100 mil habitantes (hab), e a proporção de coinfecção TB/HIV foi de 16,2%. Dados na literatura sobre casos graves de TB atendidos em Unidades de Terapia Intensiva (UTI) são escassos. O presente estudo teve como objetivo descrever aspectos sociodemográficos, clínicos, hematológicos, laboratoriais, radiológicos e variáveis associadas à letalidade em pacientes com TB internados em UTI. Trata-se de um estudo descritivo, retrospectivo, dos casos tratados para TB na UTI da Fundação de Medicina Tropical Heitor Vieira Dourado (FMT-HVD), Amazonas, no período de 2011 a 2014. Foram considerados casos de TB pacientes com baciloscopia ou cultura positiva; ou exames clínicos, clínico-radiológicos; ou critérios histopatológicos (necropsia) compatível com TB; ou menção de TB nos registros de causa básica no Sistema de Informação sobre Mortalidade (SIM) ou diagnóstico de TB no momento da alta na UTI. As informações foram obtidas por meio de prontuários eletrônicos e dos livros de admissão da UTI. No período de estudo foram incluídos 131 pacientes. A mediana de idade foi 36,4 anos, com predomínio do sexo masculino (71%). Coinfecção TB/HIV foi observada em 91,6% dos casos, desses, 87,3% apresentaram contagem de células CD4 inferior a 200 cel/mm³ e 48,9% estavam em Tratamento Antirretroviral (TARV). Tratamento anti-TB por até 30 dias anteriores à admissão na UTI foi mencionada em 56 pacientes (49,1%). De 99 pacientes que realizaram baciloscopia, 21,2% resultaram positivos, enquanto que de 87 que realizaram cultura, 27 (31,3%) confirmaram TB. Cento e dois morreram (letalidade de 77,9%), a maioria (93,1%) em menos de 28 dias de permanência na UTI. Entre pacientes HIV positivos foi mais frequente anemia hipocrômica (p=0,04), e menos frequente neutrofilia (p=0,04) e leucocitose (p=0,04). Óbito precoce (<28 dias) ocorreu mais frequentemente em pacientes sem confirmação bacteriológica (p=0,05), na forma extrapulmonar (p=0,06) em pacientes do sexo feminino com anemia (p=0,03), em Síndrome da Angústia Respiratória Aguda (SARA) (p=0,02) e baixa adesão a TARV (p=0,03). Óbito foi mais frequente em pacientes com baixa contagem de CD4 (p=0,009), uso de Ventilação Mecância (p=<0,0001) (VM), hipoalbuminemia (p=0,005) e trombocitopenia (p=<0,0001). A maioria dos pacientes recebeu o diagnóstico de TB por critério clínico (75,6%). A baciloscopia e cultura tiveram baixo desempenho. A baixa confirmação laboratorial esteve associada à elevada proporção de pacientes coinfectados por HIV e à elevada letalidade. Portanto, sugere-se a implementação de protocolos clínicos que agilizem o diagnóstico e adoção de tratamento adequado para TB em pacientes atendidos em UTI.por
dc.description.abstractTuberculosis (TB) is recognized as a serious public health problem. In Amazonas state, in 2014, TB mortality rate was 3.5/100,000 habitants, and the proportion of TB /HIV co-infection was 16.2%. Data in the literature on severe cases of TB treated in intensive care units (ICU) are scarce. This study aimed to describe socio-demographic, clinical, hematology, laboratory, radiological and variables associated with mortality in patients with TB in the ICU. It is a descriptive retrospective study of cases treated for TB in the ICU of Tropical Medicine Heitor Vieira Dourado Foundation (FMT-HVD), Amazonas, from 2011 to 2014. We considered TB cases patients with smear or positive culture; or/and clinical, clinical and radiological; or/and histopathological criteria (autopsy) compatible with TB; or/and basic cause of death records in the Mortality Information System (SIM) with mention of TB; or/and TB diagnosis at discharge ICU. The information was obtained through electronic medical records and ICU admission books. During the study period 131 patients were included. The mean age was 36.4 years, with a predominance of males (71%). TB/HIV co-infection was observed in 91.6% of cases, of these, 87.3% had CD4 cell counts below 200 cells / mm³ and 48.9% were antiretroviral therapy (ART). Anti-TB treatment for up to 30 days prior to ICU admission was mentioned in 56 patients (49.1%). 99 patients who were smear, 21.2% were positive, while 87 who underwent culture, 27 (31.3%) confirmed TB. One hundred and two died (mortality 77.9%), the majority (93.1%) in less than 28 days of stay in the ICU. Among HIV-positive patients were more frequent hypochromic anemia (p = 0.04), and less frequent neutrophil (p = 0.04) and leukocytosis (p = 0.04). Early death (<28 days) occurred more often in patients without sputum (p = 0.05), the extrapulmonary form (p = 0.06) in female patients with anemia (p = 0.03), Syndrome Acute Respiratory Distress (ARDS) (p = 0.02) and low adherence to ART (p = 0.03). Death was more frequent in patients with lower CD4 count (p = 0.009), use of mechanical ventilation (MV) (p = <0.0001), hypoalbuminemia (p = 0.005), and thrombocytopenia (p = <0.0001). In conclusion, most patients were diagnosed with TB by clinical criteria (75.6%). The smear and culture were underperforming. Low laboratory confirmation was associated with a high proportion of patients coinfected with HIV and to high mortality rates. Therefore, it is suggested the implementation of clinical protocols that streamline diagnosis and adoption of appropriate treatment for TB patients treated in the ICU.eng
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dc.thumbnail.urlhttp://tede.uea.edu.br/jspui/retrieve/1546/Tuberculose%20em%20unidade%20de%20terapia%20intensiva%20an%c3%a1lise%20Disserta%c3%a7%c3%a3o.pdf.jpg*
dc.languageporpor
dc.publisherUniversidade do Estado do Amazonaspor
dc.publisher.departmentEscola Superior de Ciências da Saúde ESA::PROPESPpor
dc.publisher.countryBrasilpor
dc.publisher.initialsUEApor
dc.publisher.programHematologiapor
dc.relation.references1. Medcalf A, Altink H, Saavedra M, Bhattacharya S. Tuberculosis. A short History. The University of York; 2013. 2. Agnaldo José Lopes, Jansen Ú, Capone D, Jansen JM. História natural e apresentação clínica. Revista Hospital Universitário Pedro Ernesto [Internet]. dezembro de 2006 [citado 11 de dezembro de 2013];5(2). Recuperado de: http://revista.hupe.uerj.br/detalhe_artigo.asp?id=232 3. Lawn SD, Zumla AI. Tuberculosis. The Lancet. julho de 2011;378(9785):57–72. 4. Harries AD, Dye C. Tuberculosis. Ann Trop Med Parasitol. setembro de 2006;100(5-6):415–31. 5. Campos HS. Etiopatogenia da tuberculose e formas clínicas. Pulmão RJ [Internet]. 2006 [citado 11 de dezembro de 2013];15(1):29–35. Recuperado de: http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS&lang=p&nextAction=lnk&exprSearch=612376&indexSearch=ID 6. Ruffino-Netto A. Recidiva da tuberculose. J Bras Pneumol [Internet]. outubro de 2007 [citado 10 de dezembro de 2013];33(5):xxvii – xxviii. Recuperado de: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132007000500001&lng=pt&nrm=iso 7. Jindal S., Shankar P., Raoof S, Gupta D, Aggarwal AN. Handobook of Pulmonary and Critical Care Medicine. 1o ed. Jaypee Brothers Medical Publishers; 2012. 808 p. 8. Lapa e Silva JR, Boéchat N. The resurgence of tuberculosis and the impact of the study of pulmonary immunopathogenesis. J Bras Pneumol [Internet]. agosto de 2004 [citado 11 de dezembro de 2013];30(4):388–94. Recuperado de: http://www.scielo.br/scielo.php?pid=S1806-37132004000400014&script=sci_arttext&tlng=en 9. Dias LC, Dessoy MA, Guido RVC, Oliva G, Andricopulo AD. Neglected tropical diseases: a new era of challenges and opportunities. Quím Nova [Internet]. janeiro de 2013 [citado 10 de fevereiro de 2015];36(10):1552–6. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422013001000011&lng=en&nrm=iso&tlng=pt 10. World Health Organization. Working to overcome the global impact of neglected tropical diseases [Internet]. WHO Library Cataloguing-in-Publication Data; 2011 [citado 9 de fevereiro de 2015]. Recuperado de: http://www.who.int/neglected_diseases/2010report/WHO_NTD_report_update_2011.pdf 11. Kaufmann SH, van Embden JD. Tuberculosis: a neglected disease strikes back. Trends Microbiol. abril de 1993;1(1):2–5. 12. Financing Global Health [Internet]. [citado 27 de janeiro de 2015]. Recuperado de: http://www.healthdata.org/data-visualization/financing-global-health 13. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, et al. Control of neglected tropical diseases. N Engl J Med. 6 de setembro de 2007;357(10):1018–27. 14. World Health Organization. AIDS epidemic update: November 2009. [Internet]. WHO Library Cataloguing-in-Publication Data; 2009 [citado 27 de janeiro de 2015]. Recuperado de: http://www.unaids.org/sites/default/files/media_asset/jc1700_epi_update_2009_en_0.pdf 15. World Health Organization. Global tuberculosis report. 20o ed 2015;204. 16. Ministério da Saúde. Boletim Epidemiológico. Tuberculose - 2015: Detectar, tratar e curar: desafios e estratégias brasileiras frente à tuberculose. 2015;46(9):19. Recuperado de: http://portalsaude.saude.gov.br/images/pdf/2015/marco/27/2015-007---BE-Tuberculose---para-substitui----o-no-site.pdf 17. Marques AMC, Cunha RV da. Assisted treatment and tuberculosis cure and treatment dropout rates in the Guaraní-Kaiwá Indian nation in the municipality of Dourados, Mato Grosso do Sul, Brazil. Cad Saúde Pública [Internet]. outubro de 2003 [citado 8 de fevereiro de 2015];19(5):1405–11. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-311X2003000500019&lng=en&nrm=iso&tlng=pt 18. Severo NPF, Leite CQF, Capela MV, Simões MJ da S. Clinical and demographic characteristics of patients hospitalized with tuberculosis in Brasil between 1994 and 2004. J Bras Pneumol Publicaça̋o Of Soc Bras Pneumol E Tisilogia. outubro de 2007;33(5):565–71. 19. Singleton L, Turner M, Haskal R, Etkind S, Tricarico M, Nardell E. Long-term hospitalization for tuberculosis control. Experience with a medical-psychosocial inpatient unit. JAMA. 10 de setembro de 1997;278(10):838– 20. Nogueira PA. Reasons for the admission, length of stay and type of discharge in tuberculosis hospitals in the State of São Paulo, Brazil -- 1981 to 1995. J Pneumol [Internet]. maio de 2001 [citado 8 de fevereiro de 2015];27(3):123–9. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-35862001000300001&lng=en&nrm=iso&tlng=pt 21. Greenaway C, Menzies D, Fanning A, Grewal R, Yuan L, FitzGerald JM, et al. Delay in diagnosis among hospitalized patients with active tuberculosis--predictors and outcomes. Am J Respir Crit Care Med. 1 de abril de 2002;165(7):927–33. 22. Hansel NN, Merriman B, Haponik EF, Diette GB. Hospitalizations for tuberculosis in the united states in 2000*: Predictors of in-hospital mortality. Chest [Internet]. 1 de outubro de 2004 [citado 8 de fevereiro de 2015];126(4):1079–86. Recuperado de: http://dx.doi.org/10.1378/chest.126.4.1079 23. Kirenga BJ, Levin J, Ayakaka I, Worodria W, Reilly N, Mumbowa F, et al. Treatment outcomes of new tuberculosis patients hospitalized in Kampala, Uganda: a prospective cohort study. PloS One. 2014;9(3):e90614. 24. Erhabor GE, Adewole OO, Ogunlade O. A five-year review of tuberculosis mortality amongst hospitalised patients in Ile-Ife. Indian J Chest Dis Allied Sci. dezembro de 2006;48(4):253–6. 25. Blanc F-X, Sok T, Laureillard D, Borand L, Rekacewicz C, Nerrienet E, et al. Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. N Engl J Med. 20 de outubro de 2011;365(16):1471–81. 26. Abdullah AA, Yaseen MA, Hamdan A-J, Ashwaq O, Othman AH, Ziad M. Clinical presentation and outcome of patients diagnosed with active pulmonary tuberculosis in a large critical care unit. 2011;(Crit Care & Shock):6. Recuperado de: http://criticalcareshock.org 27. Zahar JR, Azoulay E, Klement E, De Lassence A, Lucet JC, Regnier B, et al. Delayed treatment contributes to mortality in ICU patients with severe active pulmonary tuberculosis and acute respiratory failure. Intensive Care Med. março de 2001;27(3):513–20. 28. Ryu YJ, Koh W-J, Kang EH, Suh GY, Chung MP, Kim H, et al. Prognostic factors in pulmonary tuberculosis requiring mechanical ventilation for acute respiratory failure. Respirol Carlton Vic. maio de 2007;12(3):406–11. 29. Greenaway C, Menzies D, Fanning A, Grewal R, Yuan L, FitzGerald JM, et al. Delay in diagnosis among hospitalized patients with active tuberculosis--predictors and outcomes. Am J Respir Crit Care Med. 1 de abril de 2002;165(7):927–33. 30. Farah MG, Rygh JH, Steen TW, Selmer R, Heldal E, Bjune G. Patient and health care system delays in the start of tuberculosis treatment in Norway. BMC Infect Dis. 2006;6:33. 31. Maior M de L, Guerra RL, Cailleaux-Cezar M, Golub JE, Conde MB. Time from symptom onset to the initiation of treatment of pulmonary tuberculosis in a city with a high incidence of the disease. J Bras Pneumol [Internet]. abril de 2012 [citado 26 de novembro de 2014];38(2):202–9. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1806-37132012000200009&lng=en&nrm=iso&tlng=pt 32. Kim JY, Park YB, Kim YS, Kang SB, Shin JW, Park IW, et al. Miliary tuberculosis and acute respiratory distress syndrome. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. abril de 2003;7(4):359–64. 33. Verdon R, Chevret S, Laissy JP, Wolff M. Tuberculous meningitis in adults: review of 48 cases. Clin Infect Dis Off Publ Infect Dis Soc Am. junho de 1996;22(6):982–8. 34. Domingos MP, Caiaffa WT, Colosimo EA. Mortality, TB/HIV co-infection, and treatment dropout: predictors of tuberculosis prognosis in Recife, Pernambuco State, Brazil. Cad Saúde Pública. abril de 2008;24(4):887– 35. Nagai H. [Factors for the onset of and the exacerbation of tuberculosis. 5. The infection and prognosis of tuberculosis among patients with immunodeficiency, especially HIV-infected patients]. Kekkaku. outubro de 1999;74(10):753–8. 36. Whalen CC, Nsubuga P, Okwera A, Johnson JL, Hom DL, Michael NL, et al. Impact of pulmonary tuberculosis on survival of HIV-infected adults: a prospective epidemiologic study in Uganda. AIDS Lond Engl. 16 de junho de 2000;14(9):1219–28. 37. Keiper MD, Beumont M, Elshami A, Langlotz CP, Miller WT. CD4 T lymphocyte count and the radiographic presentation of pulmonary tuberculosis. A study of the relationship between these factors in patients with human immunodeficiency virus infection. Chest. janeiro de 1995;107(1):74–80. 38. Besen A, Staub GJ, Silva RM da. Clinical, radiological, and laboratory characteristics in pulmonary tuberculosis patients: comparative study of HIV-positive and HIV-negative inpatients at a referral hospital. J Bras Pneumol [Internet]. dezembro de 2011 [citado 27 de novembro de 2014];37(6):768–75. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1806-37132011000600010&lng=en&nrm=iso&tlng=pt 39. Santos Neto M, Silva FL da, Sousa KR de, Yamamura M, Popolin MP, Arcêncio RA. Clinical and epidemiological profile and prevalence of tuberculosis/HIV co-infection in a regional health district in the state of Maranhão, Brazil. J Bras Pneumol [Internet]. dezembro de 2012 [citado 3 de dezembro de 2014];38(6):724–32. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1806-37132012000600007&lng=en&nrm=iso&tlng=pt 40. De Souza MVN. Tuberculose em pacientes HIV-positivos, um grave problema de saúde mundial. 2006 [citado 4 de dezembro de 2014];87(Revista Brasileira de Far-Manguinhos):42–4. Recuperado de: http://scholar.google.com.br/scholar?q=Tuberculose+em+pacientes+HIV-positivos,+um+grave+problema+de+sa%C3%BAde+mundial&hl=pt-BR&as_sdt=0&as_vis=1&oi=scholart&sa=X&ei=wXCAVLrfOYeeNsj2gbgI&ved=0CBwQgQMwAA 41. Jamal LF, Moherdaui F. Tuberculosis and HIV infection in Brazil: magnitude of the problem and strategies for control. Rev Saúde Pública [Internet]. setembro de 2007 [citado 5 de dezembro de 2014];41:104–10. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0034-89102007000800014&lng=en&nrm=iso&tlng=pt 42. Carvalho LGM de, Buani AZ, Zöllner MSA da C, Scherma AP. Co-infection with Mycobacterium tuberculosis and human immunodeficiency virus: an epidemiological analysis in the city of Taubaté, Brazil. J Bras Pneumol [Internet]. outubro de 2006 [citado 4 de dezembro de 2014];32(5):424–9. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1806-37132006000500009&lng=en&nrm=iso&tlng=pt 43. Katz I, Rosenthal T, Michaeli D. Undiagnosed tuberculosis in hospitalized patients. Chest. junho de 1985;87(6):770–4. 44. Lui G, Wong RYK, Li F, Lee MKP, Lai RWM, Li TCM, et al. High mortality in adults hospitalized for active tuberculosis in a low HIV prevalence setting. PloS One. 2014;9(3):e92077. 45. Frame RN, Johnson MC, Eichenhorn MS, Bower GC, Popovich JJ. Active tuberculosis in the medical intensive care unit: a 15-year retrospective analysis. Crit Care Med. novembro de 1987;15(11):1012–4. 46. Soeiro A de M, Parra ER, Canzian M, Farhat C, Capelozzi VL. Pulmonary histopathological alterations in patients with acute respiratory failure: an autopsy study. J Bras Pneumol Publicaça̋o Of Soc Bras Pneumol E Tisilogia. fevereiro de 2008;34(2):67–73. 47. Silva DR, Menegotto DM, Schulz LF, Gazzana MB, Dalcin PT. Mortality among patients with tuberculosis requiring intensive care: a retrospective cohort study. BMC Infect Dis. 2010;10:54. 48. Heffner JE, Strange C, Sahn SA. The impact of respiratory failure on the diagnosis of tuberculosis. Arch Intern Med. maio de 1988;148(5):1103–8. 49. Yaranal PJ, Umashankar T, Harish SG. Hematological Profile in Pulmonary Tuberculosis. Int J Health Rehabil Sci IJHRS [Internet]. 2013 [citado 18 de maio de 2015];2(1):50–5. Recuperado de: http://www.scopemed.org/?mno=34274 50. Shafee M, Abbas F, Ashraf M, Alam Mengal M, Kakar N, Ahmad Z, et al. Hematological profile and risk factors associated with pulmonary tuberculosis patients in Quetta, Pakistan. Pak J Med Sci [Internet]. 2014 [citado 18 de maio de 2015];30(1):36–40. Recuperado de: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955538/ 51. Oliveira MG, Delogo KN, Oliveira HM de MG de, Ruffino-Netto A, Kritski AL, Oliveira MM. Anemia in hospitalized patients with pulmonary tuberculosis. J Bras Pneumol Publicaça̋o Of Soc Bras Pneumol E Tisilogia. agosto de 2014;40(4):403–10. 52. Nogueira CR, Chaves GV, Teixeira MT, Franc CA da S, Ramalho A. Aspectos antropométricos, bioquímicos e sintomatológicos em mulheres com tuberculose pulmonar. Rev Ciênc Médicas [Internet]. 13 de novembro de 2012 [citado 10 de dezembro de 2014];15(4). Recuperado de: http://periodicos.puc-campinas.edu.br/seer/index.php/cienciasmedicas/article/view/1098 53. Oppenheimer SJ. Iron and Its Relation to Immunity and Infectious Disease. J Nutr [Internet]. 2 de janeiro de 2001 [citado 12 de dezembro de 2014];131(2):616S – 635S. Recuperado de: http://jn.nutrition.org/content/131/2/616S 54. Morris CD, Bird AR, Nell H. The haematological and biochemical changes in severe pulmonary tuberculosis. Q J Med. dezembro de 1989;73(272):1151–9. 55. Mofenson LM, Harris DR, Moye J, Bethel J, Korelitz J, Read JS, et al. Alternatives to HIV-1 RNA concentration and CD4 count to predict mortality in HIV-1-infected children in resource-poor settings. Lancet. 15 de novembro de 2003;362(9396):1625–7. 56. De Santis GC, Brunetta DM, Vilar FC, Brandão RA, de Albernaz Muniz RZ, de Lima GMN, et al. Hematological abnormalities in HIV-infected patients. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. dezembro de 2011;15(12):e808–11. 57. Mekonnen Y, Dukers NH, Sanders E, Dorigo W, Wolday D, Schaap A, et al. Simple markers for initiating antiretroviral therapy among HIV-infected Ethiopians. Ethiop Med J. junho de 2003;41 Suppl 1:61–5. 58. Antelman G, Msamanga GI, Spiegelman D, Urassa EJ, Narh R, Hunter DJ, et al. Nutritional factors and infectious disease contribute to anemia among pregnant women with human immunodeficiency virus in Tanzania. J Nutr. agosto de 2000;130(8):1950–7. 69 59. Evans RH, Scadden DT. Haematological aspects of HIV infection. Baillières Best Pract Res Clin Haematol. junho de 2000;13(2):215–30. 60. Ballem PJ, Belzberg A, Devine DV, Lyster D, Spruston B, Chambers H, et al. Kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection. N Engl J Med. 17 de dezembro de 1992;327(25):1779–84. 61. Kourbatova EV, Borodulin BE, Borodulina EA, del Rio C, Blumberg HM, Leonard MK. Risk factors for mortality among adult patients with newly diagnosed tuberculosis in Samara, Russia. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. novembro de 2006;10(11):1224–30. 62. Ciglenecki I, Glynn JR, Mwinga A, Ngwira B, Zumla A, Fine PEM, et al. Population differences in death rates in HIV-positive patients with tuberculosis. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. outubro de 2007;11(10):1121–8. 63. Dye C, Williams BG. The Population Dynamics and Control of Tuberculosis. Science [Internet]. 14 de maio de 2010 [citado 27 de maio de 2014];328(5980):856–61. Recuperado de: http://www.sciencemag.org/content/328/5980/856 64. Bleed D, Dye C, Raviglione MC. Dynamics and control of the global tuberculosis epidemic. Curr Opin Pulm Med. maio de 2000;6(3):174–9. 65. Frieden TR. Can tuberculosis be controlled? Int J Epidemiol. outubro de 2002;31(5):894–9. 66. Frothingham R, Stout JE, Hamilton CD. Current issues in global tuberculosis control. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. novembro de 2005;9(6):297–311. 67. Netto RA. Programa de Controle da Tuberculose no Brasil: Situação Atual e Novas Perspectivas. 2011 [citado 27 de junho de 2015];(Departamento de Medicina Social/Faculdade de Medicina de Ribeirão Preto/USP):10. Recuperado de: http://scielo.iec.pa.gov.br/pdf/iesus/v10n3/v10n3a04.pdf 68. Elkington PT. Tuberculosis: time for a new perspective? J Infect. abril de 2013;66(4):299–302. 69. National Collaborating Centre for Chronic Conditions (UK), Centre for Clinical Practice at NICE (UK). Tuberculosis: Clinical Diagnosis and Management of Tuberculosis, and Measures for Its Prevention and Control [Internet]. London: National Institute for Health and Clinical Excellence (UK); 2011 [citado 12 de fevereiro de 2015]. Recuperado de: http://www.ncbi.nlm.nih.gov/books/NBK97852/ 70. WHO | Treatment of tuberculosis: guidelines for national programmes. WHO. 2010. 71. Hagan G, Nathani N. Clinical review: tuberculosis on the intensive care unit. Crit Care Lond Engl. 2013;17(5):240. 72. Joaquim AF, Carandina L, Defaveri J. Tuberculosis in necropsies performed at the Department of Pathology of Botucatu Medical School. J Bras Patol E Med Lab [Internet]. junho de 2006 [citado 21 de maio de 2015];42(3):193–200. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1676-24442006000300008&lng=en&nrm=iso&tlng=pt 73. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia anda assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, 2011 (WHO/NMH/NHD/MNM/11.1. 2011 [citado 21 de maio de 2015];6. Recuperado de: http://www.who.int/vmnis/indicators/haemoglobin.pdf 74. Balkema CA, Irusen EM, Taljaard JJ, Koegelenberg CFN. Tuberculosis in the intensive care unit: a prospective observational study. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. julho de 2014;18(7):824–30. 75. Erbes R, Oettel K, Raffenberg M, Mauch H, Schmidt-Ioanas M, Lode H. Characteristics and outcome of patients with active pulmonary tuberculosis requiring intensive care. Eur Respir J. junho de 2006;27(6):1223–8. 76. Lanoix J-P, Gaudry S, Flicoteaux R, Ruimy R, Wolff M. Tuberculosis in the intensive care unit: a descriptive analysis in a low-burden country. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. maio de 2014;18(5):581–7. 77. Valade S, Raskine L, Aout M, Malissin I, Brun P, Deye N, et al. Tuberculosis in the intensive care unit: A retrospective descriptive cohort study with determination of a predictive fatality score. Can J Infect Dis Med Microbiol J Can Mal Infect Microbiol Médicale AMMI Can. 2012;23(4):173–8. 78. Sterling T, Cathy Jenkins, Karu Jayathilake, Eduardo Gotuzzo, Valdilea Veloso, Claudia P. Cortes, et al. Culture-Negative TB Is Associated With Increased Mortality in HIV-Infected Persons. 2015 [citado 3 de junho de 2015]; Recuperado de: http://www.croiconference.org/sites/default/files/uploads/croi2015-program-at-a-glance.pdf 79. Ministério da Saúde. Boletim epidemiológico HIV-AIDS. 2014 [citado 22 de maio de 2015];3:84. Recuperado de: http://www.aids.gov.br/sites/default/files/anexos/publicacao/2014/56677/boletim_2014_1_pdf_60254.pdf 80. Addis Alene K, Nega A, Wasie Taye B. Incidence and predictors of tuberculosis among adult people living with human immunodeficiency virus at the University of Gondar Referral Hospital, Northwest Ethiopia. BMC Infect Dis. 2013;13:292. 81. Silva DR, da Silva LP, Dalcin P de TR. Tuberculosis in hospitalized patients: clinical characteristics of patients receiving treatment within the first 24 h after admission. J Bras Pneumol [Internet]. 2014 [citado 4 de maio de 2015];40(3):279–85. Recuperado de: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109200/ 82. Lee PL, Jerng JS, Chang YL, Chen CF, Hsueh PR, Yu CJ, et al. Patient mortality of active pulmonary tuberculosis requiring mechanical ventilation. Eur Respir J. julho de 2003;22(1):141–7. 83. Malhotra P, Agarwal R, Gupta D, Aggarwal AN. Successful management of ARDS with bronchopleural fistula secondary to miliary tuberculosis using a conventional ventilator. Monaldi Arch Chest Dis Arch Monaldi Mal Torace Fondazione Clin Lav IRCCS Ist Clin Tisiol E Mal Appar Respir Univ Napoli Secondo Ateneo. setembro de 2005;63(3):163–5. 84. Wallace JM, Hansen NI, Lavange L, Glassroth J, Browdy BL, Rosen MJ, et al. Respiratory disease trends in the Pulmonary Complications of HIV Infection Study cohort. Pulmonary Complications of HIV Infection Study Group. Am J Respir Crit Care Med. janeiro de 1997;155(1):72–80. 85. Batista J d’Arc L, de Albuquerque M de FPM, Maruza M, Ximenes RA de A, Santos ML, Montarroyos UR, et al. Incidence and risk factors for tuberculosis in people living with HIV: cohort from HIV referral health centers in Recife, Brazil. PloS One. 2013;8(5):e63916. 86. Manosuthi W, Chottanapand S, Thongyen S, Chaovavanich A, Sungkanuparph S. Survival rate and risk factors of mortality among HIV/tuberculosis-coinfected patients with and without antiretroviral therapy. J Acquir Immune Defic Syndr 1999. setembro de 2006;43(1):42–6. 87. Van Rie A, Westreich D, Sanne I. Tuberculosis in patients receiving antiretroviral treatment: incidence, risk factors and prevention strategies. J Acquir Immune Defic Syndr 1999 [Internet]. abril de 2011 [citado 7 de maio de 2015];56(4):349–55. Recuperado de: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319435/ 88. Kerkhoff AD, Wood R, Cobelens FG, Gupta-Wright A, Bekker L-G, Lawn SD. The predictive value of current haemoglobin levels for incident tuberculosis and/or mortality during long-term antiretroviral therapy in South Africa: a cohort study. BMC Med [Internet]. 2 de abril de 2015 [citado 21 de maio de 2015];13(1):70. Recuperado de: http://www.biomedcentral.com/1741-7015/13/70/abstract 89. Parinitha S, Kulkarni M. Haematological changes in HIV infection with correlation to CD4 cell count. Australas Med J. 2012;5(3):157–62. 90. Belperio PS, Rhew DC. Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: a systematic review of the literature. Am J Med. 5 de abril de 2004;116 Suppl 7A:27S – 43S. 91. Saathoff E, Villamor E, Mugusi F, Bosch RJ, Urassa W, Fawzi WW. Anemia in adults with tuberculosis is associated with HIV and anthropometric status in Dar es Salaam, Tanzania. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. julho de 2011;15(7):925–32. 92. Enawgaw B, Alem M, Addis Z, Melku M. Determination of hematological and immunological parameters among HIV positive patients taking highly active antiretroviral treatment and treatment naïve in the antiretroviral therapy clinic of Gondar University Hospital, Gondar, Northwest Ethiopia: a comparative cross-sectional study. BMC Hematol [Internet]. 25 de março de 2014 [citado 20 de maio de 2015];14(1):8. Recuperado de: http://www.biomedcentral.com/2052-1839/14/8/abstract 93. Patwardhan MS, Golwilkar AS, Abhyankar JR, Atre MC. Hematological profile of HIV positive patients. Indian J Pathol Microbiol. abril de 2002;45(2):147–50. 94. Siddiqi K, Lambert M-L, Walley J. Clinical diagnosis of smear-negative pulmonary tuberculosis in low-income countries: the current evidence. Lancet Infect Dis. maio de 2003;3(5):288–96. 95. Hargreaves NJ, Kadzakumanja O, Whitty CJ, Salaniponi FM, Harries AD, Squire SB. “Smear-negative” pulmonary tuberculosis in a DOTS programme: poor outcomes in an area of high HIV seroprevalence. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. setembro de 2001;5(9):847–54. 96. Singhal S, Mahajan SN, Diwan SK, Gaidhane A, Quazi ZS. Correlation of sputum smear status with CD4 count in cases of pulmonary tuberculosis and HIV co-infected patients--a hospital based study in a rural area of Central India. Indian J Tuberc. julho de 2011;58(3):108–12. 97. Hui C, Wu C-L, Chan M-C, Kuo I-T, Chiang C-D. Features of severe pneumonia in patients with undiagnosed pulmonary tuberculosis in an intensive care unit. J Formos Med Assoc Taiwan Yi Zhi. agosto de 2003;102(8):563–9. 98. Wu J-Y, Ku S-C, Shu C-C, Fan J-Y, Chen H-Y, Chen Y-C, et al. The role of chest radiography in the suspicion for and diagnosis of pulmonary tuberculosis in intensive care units. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. novembro de 2009;13(11):1380–6. 99. Jr S, Da JB. Tuberculose: Guia de Vigilância Epidemiológica. J Bras Pneumol [Internet]. junho de 2004 [citado 21 de maio de 2015];30:S57–86. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1806-37132004000700003&lng=en&nrm=iso&tlng=pt 100. Bisaso KR, Owen JS, Ojara FW, Namuwenge PM, Mugisha A, Mbuagbaw L, et al. Characterizing plasma albumin concentration changes in TB/HIV patients on anti retroviral and anti -tuberculosis therapy. Silico Pharmacol. 2014;2(1):3. 101. Moore D, Liechty C, Ekwaru P, Were W, Mwima G, Solberg P, et al. Prevalence, incidence and mortality associated with tuberculosis in HIV-infected patients initiating antiretroviral therapy in rural Uganda. AIDS Lond Engl. 30 de março de 2007;21(6):713–9. 102. Macpherson P, Dimairo M, Bandason T, Zezai A, Munyati SS, Butterworth AE, et al. Risk factors for mortality in smear-negative tuberculosis suspects: a cohort study in Harare, Zimbabwe. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. outubro de 2011;15(10):1390–6. 103. Achi HV, Ahui BJM, Anon J-C, Kouassi BA, Dje-Bi H, Kininlman H. [Pancytopenia: a severe complication of miliary tuberculosis]. Rev Mal Respir. janeiro de 2013;30(1):33–7. 104. Machado AC de FT, Steffen RE, Oxlade O, Menzies D, Kritski A, Trajman A. Factors associated with delayed diagnosis of pulmonary tuberculosis in the state of Rio de Janeiro, Brazil. J Bras Pneumol [Internet]. agosto de 2011 [citado 30 de maio de 2015];37(4):512–20. Recuperado de: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1806-37132011000400014&lng=en&nrm=iso&tlng=pt 105. Thomas B, Suhadev M, Mani J, Ganapathy BG, Armugam A, Faizunnisha F, et al. Feasibility of an Alcohol Intervention Programme for TB Patients with Alcohol Use Disorder (AUD) - A Qualitative Study from Chennai, South India. PLoS ONE [Internet]. 21 de novembro de 2011 [citado 30 de maio de 2015];6(11):e27752. Recuperado de: http://dx.doi.org/10.1371/journal.pone.0027752 106. Deiss RG, Rodwell TC, Garfein RS. Tuberculosis and Drug Use: Review and Update. Clin Infect Dis Off Publ Infect Dis Soc Am [Internet]. 1 de janeiro de 2009 [citado 30 de maio de 2015];48(1). Recuperado de: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110742/ 107. Madkour A, Fouda M, Mansour M. Outcome of active pulmonary tuberculosis patients requiring respiratory intensive care admission. Egypt J Bronchol [Internet]. 2014 [citado 14 de abril de 2015];8(2):79. Recuperado de: http://www.ejbronchology.eg.net/text.asp?2014/8/2/79/145692 108. Harries AD, Hargreaves NJ, Gausi F, Kwanjana JH, Salaniponi FM. High early death rate in tuberculosis patients in Malawi. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. novembro de 2001;5(11):1000–por
dc.rightsAcesso Abertopor
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectTurbeculosepor
dc.subjectHIVpor
dc.subjectLetalidadepor
dc.subjectUTIpor
dc.subjectCoinfecçãopor
dc.subject.cnpqCIENCIAS DA SAUDEpor
dc.subject.cnpqCIENCIAS DA SAUDE::SAUDE COLETIVApor
dc.subject.cnpqSAUDE COLETIVA::MEDICINA PREVENTIVApor
dc.titleTuberculose em unidade de terapia intensiva: análise descritiva em um hospital de referência HIV / AIDS na amazônia brasileirapor
dc.title.alternativeTuberculosis in an intensive care unit: descriptive analysis in a hospital of reference HIV / AIDS in the Brazilian Amazoneng
dc.typeDissertaçãopor
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